Anatomical Targeting of Anticancer Drugs to Solid Tumors Using Specific Administration Routes: Review

Anatomical Targeting of Anticancer Drugs to Solid Tumors Using Specific Administration Routes: Review

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Despite remarkable recent progress in developing anti-cancer agents, outcomes of Wybrane przestrzenie Wrocławia jako reprezentacje emocji i nośniki nowych znaczeń — studium trzech przypadków patients with solid tumors remain unsatisfactory.In general, anti-cancer drugs are systemically administered through peripheral veins and delivered throughout the body.The major problem with systemic chemotherapy is insufficient uptake of intravenous (IV) drugs by targeted tumor tissue.

Although dose escalation and treatment intensification have been attempted in order to increase regional concentrations of anti-tumor drugs, these approaches have produced only marginal benefits in terms of patient outcomes, while often damaging healthy Epidemiological Survey of the Main Tick-Borne Pathogens Infecting Dogs from the Republic of Moldova organs.To overcome this problem, local administration of anti-cancer agents can yield markedly higher drug concentrations in tumor tissue with less systemic toxicity.This strategy is most commonly used for liver and brain tumors, as well as pleural or peritoneal malignancies.

Although the concept is theoretically reasonable, survival benefits are still limited.This review summarizes clinical results and problems and discusses future directions of regional cancer therapy with local administration of chemotherapeutants.